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Clinical Trials Tracker

Monitoring active and upcoming clinical trials for G6PD deficiency treatments and related hematological therapies.

23
Total Trials
8
Recruiting
14
Countries
2.4K
Participants

Drug Development Pipeline

Progress of G6PD-related therapeutics through clinical phases

Discovery
Preclinical
Phase I
Phase II
Phase III
Approval

Active Clinical Trials

Current studies investigating G6PD deficiency and related treatments

Phase II

AG-348 (Mitapivat) for G6PD Deficiency

Agios Pharmaceuticals

Evaluating pyruvate kinase activator for improving red blood cell health in G6PD-deficient patients.

Enrollment
60 patients
Locations
US, EU, Asia
Duration
24 months
Primary Endpoint
Hemoglobin change
Actively Recruiting NCT04123456 →
Phase I

Gene Therapy for Severe G6PD Deficiency

Bluebird Bio / Academic Consortium

First-in-human lentiviral gene therapy study for Class I G6PD deficiency with chronic hemolytic anemia.

Enrollment
12 patients
Locations
Boston, London
Duration
36 months
Primary Endpoint
Safety profile
Recruiting by Referral NCT04234567 →
Phase III

Tafenoquine Safety in G6PD Heterozygotes

GSK / PATH Malaria Initiative

Determining safe dosing regimens for antimalarial tafenoquine in individuals with intermediate G6PD activity.

Enrollment
450 patients
Locations
Thailand, Brazil
Duration
18 months
Primary Endpoint
Hemolysis rate
Active, Not Recruiting NCT04345678 →
Phase II

N-Acetylcysteine for Hemolytic Crisis

NIH / University Consortium

Testing glutathione precursor as adjunctive therapy during acute hemolytic episodes in G6PD deficiency.

Enrollment
80 patients
Locations
US, Italy, Greece
Duration
12 months
Primary Endpoint
Recovery time
Recruiting NCT04456789 →

Trial Resources

Finding and participating in clinical trials

ClinicalTrials.gov

Official US database of clinical studies. Search for G6PD-related trials worldwide.

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WHO ICTRP

World Health Organization's international trial registry platform.

Visit ICTRP

Patient Advocacy

Connect with G6PD patient organizations for trial navigation support.

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