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G6PD Variant Database

Explore over 200 documented G6PD variants with clinical classifications, enzyme activity levels, and geographic distributions.

All Classes Class I Class II Class III Class IV
217
Total Variants
54
Class I (Severe)
89
Class II (Moderate)
400M+
People Affected

Common Variants

The most clinically significant G6PD variants worldwide

Variant Name Mutation Class Activity Prevalence
G6PD Mediterranean S188F Class II 0-10% Mediterranean, Middle East
G6PD A- V68M + N126D Class III 8-20% Sub-Saharan Africa
G6PD Canton R459L Class II 4-25% Southeast Asia, China
G6PD Mahidol G163S Class III 5-32% Thailand, Myanmar
G6PD Seattle D282H Class IV 60-100% Sardinia, Papua New Guinea
G6PD Orissa A44G Class III 10-25% India
G6PD Vanua Lava L128P Class II 1-7% Vanuatu, Pacific Islands
G6PD Aurès I48T Class II 5-10% North Africa

Enzyme Activity Comparison

Residual enzyme activity levels across different variant classes

Wild Type
100%
Class IV
60-100%
Class III
10-60%
Class II
<10%
Class I
<5%

WHO Classification System

Class I: Chronic hemolytic anemia with severe enzyme deficiency
Class II: Severe enzyme deficiency (<10% activity)
Class III: Moderate enzyme deficiency (10-60% activity)
Class IV: Normal enzyme activity (60-100%)

Geographic Distribution

G6PD deficiency prevalence correlates with historical malaria-endemic regions

>20%
10-20%
5-10%
1-5%
<1%
20-30%
Sub-Saharan Africa
5-25%
Mediterranean
3-15%
Southeast Asia